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1

The function of alkaline phosphatase in the liver: Regulation of intrahepatic biliary epithelium secretory activities in the rat

Domenico Alvaro, Antonio Benedetti, Luca Marucci, Marco Delle Monache, Rita Monterubbianesi, Emanuele Di Cosimo, Lucia Perego, Giampiero Macarri, Shannon Glaser, Gene Le Sage, Gianfranco Alpini

Journal:

Year:

2000

Language:

english

File:

PDF, 589 KB

english, 2000

2

The blockage of endogenous cholangiocyte serotonin secretion enhances the growth of the biliary tree after bile duct ligation (BDL): Evidence for autocrine regulation of cholangiocyte proliferation

Marzioni, Marco, Glaser, Shannon, Francis, Heather, Marucci, Luca, Benedetti, Antonio, Ueno, Yoshiyuki, Venter, Julie, Baumann, Brandy, Phinizy, Jo Lynne, Alpini, Gianfranco

Journal:

Gastroenterology

Year:

2003

Language:

english

File:

PDF, 265 KB

english, 2003

3

Mo1470 Activation of the Apelin(Apelin Receptor Axis in Cholangiocarcinoma Promotes Tumor Growth and Angiogenesis

Hall, Chad, Ehrlich, Laurent, White, Tori, O'Brien, April, Lairmore, Terry C., Alpini, Gianfranco, Glaser, Shannon

Journal:

Gastroenterology

Year:

2016

Language:

english

File:

PDF, 130 KB

english, 2016

4

243 - In Vitro Formation of Three-Dimensional Biliary Trees Within Decellularized Liver Extracellular Matrix Hydrogels

Lewis, Phillip L., Su, Jimmy, Venter, Julie, Meng, Fanyin, Glaser, Shannon, Green, Richard M., Alpini, Gianfranco, Sosa-Pineda, Beatriz, Shah, Ramille N.

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 705 KB

english, 2018

5

Hepatitis C virus infection and cholangiocarcinoma: An insight into epidemiological evidences and hypothetical mechanisms of oncogenesis

Navas, Maria-Cristina, Glaser, Shannon, Dhruv, Harshil, Celinski, Scott, Alpini, Gianfranco, Meng, Fanyin

Journal:

The American Journal of Pathology

Year:

2019

Language:

english

File:

PDF, 2.23 MB

english, 2019

6

Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats

Gianfranco Alpini, Shannon Glaser, Leonardo Baiocchi, Heather Francis, Xuefeng Xia, Gene LeSage

Journal:

Year:

2005

Language:

english

File:

PDF, 439 KB

english, 2005

7

Diferentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation

Mario Strazzabosco, Romina Fiorotto, Saida Melero, Shannon Glaser, Heather Francis, Carlo Spirli, Gianfranco Alpini

Journal:

Year:

2009

Language:

english

File:

PDF, 620 KB

english, 2009

8

Activation of the cholehepatic shunt as a potential therapy for primary sclerosing cholangitis

Shannon S. Glaser, Gianfranco Alpini

Journal:

Year:

2009

Language:

english

File:

PDF, 119 KB

english, 2009

9

Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation

Shannon Glaser, Ian P. Lam, Antonio Franchitto, Eugenio Gaudio, Paolo Onori, Billy K. Chow, Candace Wise, Shelley Kopriva, Julie Venter, Mellanie White, Yoshiyuki Ueno, David Dostal, Guido Carpino, Ro

Journal:

Year:

2010

Language:

english

File:

PDF, 970 KB

english, 2010

10

Adenosine triphosphate release and purinergic (P2) receptor–mediated secretion in small and large mouse cholangiocytes

Kangmee Woo, Meghana Sathe, Charles Kresge, Victoria Esser, Yoshiyuki Ueno, Julie Venter, Shannon S. Glaser, Gianfranco Alpini, Andrew P. Feranchak

Journal:

Year:

2010

Language:

english

File:

PDF, 590 KB

english, 2010

11

Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration

Fanyin Meng, Heather Francis, Shannon Glaser, Yuyan Han, Sharon DeMorrow, Allison Stokes, Dustin Staloch, Julie Venter, Melanie White, Yoshiyuki Ueno, Lola M. Reid, Gianfranco Alpini

Journal:

Year:

2012

Language:

english

File:

PDF, 1.96 MB

english, 2012

12

Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver

Gene D. LeSage, Antonio Benedetti, Shannon Glaser, Luca Marucci, Ziga Tretjak, Alessandra Caligiuri, Rebecca Rodgers, Jo Lynne Phinizy, Leonardo Baiocchi, Heather Francis, John Lasater, Laura Ugili, G

Journal:

Year:

1999

Language:

english

File:

PDF, 886 KB

english, 1999

13

Functional heterogeneity of the intrahepatic biliary epithelium

Noriatsu Kanno, Gene LeSage, Shannon Glaser, Domenico Alvaro, Assistant Professor Gianfranco Alpini

Journal:

Year:

2000

Language:

english

File:

PDF, 241 KB

english, 2000

14

Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor

Paolo Onori, Candace Wise, Eugenio Gaudio, Antonio Franchitto, Heather Francis, Guido Carpino, Vien Lee, Ian Lam, Timothy Miller, David E. Dostal, Shannon S. Glaser

Journal:

International Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 1.56 MB

english, 2010

15

Trifluoromethyl ketones as inhibitors of histone deacetylase

Robin R. Frey, Carol K. Wada, Robert B. Garland, Michael L. Curtin, Michael R. Michaelides, Junling Li, Lori J. Pease, Keith B. Glaser, Patrick A. Marcotte, Jennifer J. Bouska, Shannon S. Murphy, Stev

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 157 KB

english, 2002

16

α-Keto amides as inhibitors of histone deacetylase

Carol K. Wada, Robin R. Frey, Zhiqin Ji, Michael L. Curtin, Robert B. Garland, James H. Holms, Junling Li, Lori J. Pease, Jun Guo, Keith B. Glaser, Patrick A. Marcotte, Paul L. Richardson, Shannon S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 258 KB

english, 2003

17

Regulation of cholangiocyte proliferation

Gene LeSage, Shannon Glaser, Gianfranco Alpini

Journal:

Liver International

Year:

2001

Language:

english

File:

PDF, 270 KB

english, 2001

18

Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms

Silvia Taffetani, Shannon Glaser, Heather Francis, Sharon DeMorrow, Yoshiyuki Ueno, Domenico Alvaro, Luca Marucci, Marco Marzioni, Giammarco Fava, Julie Venter, Shelley Vaculin, Bradley Vaculin, Ian P

Journal:

Year:

2007

Language:

english

File:

PDF, 3.14 MB

english, 2007

19

Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice

Yoshiyuki Ueno, Gianfranco Alpini, Kaichiro Yahagi, Noriatsu Kanno, Yuki Moritoki, Koji Fukushima, Shannon Glaser, Gene LeSage, Tooru Shimosegawa

Journal:

Liver International

Year:

2003

Language:

english

File:

PDF, 813 KB

english, 2003

20

Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver

Marco Marzioni, Yoshiyuki Ueno, Shannon Glaser, Heather Francis, Antonio Benedetti, Domenico Alvaro, Juliet Venter, Giammarco Fava, Gianfranco Alpini

Journal:

Liver International

Year:

2007

Language:

english

File:

PDF, 768 KB

english, 2007

21

Biliary atresia: is lack of innate immune response tolerance key to pathogenesis?

Shannon S. Glaser

Journal:

Liver International

Year:

2008

Language:

english

File:

PDF, 47 KB

english, 2008

22

Endothelin inhibits cholangiocarcinoma growth by a decrease in the vascular endothelial growth factor expression

Giammarco Fava, Sharon DeMorrow, Eugenio Gaudio, Antonio Franchitto, Paolo Onori, Guido Carpino, Shannon Glaser, Heather Francis, Monique Coufal, Luca Marucci, Domenico Alvaro, Marco Marzioni, Trenton

Journal:

Liver International

Year:

2009

Language:

english

File:

PDF, 1.97 MB

english, 2009

23

Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium

Glaser, Shannon S, Gaudio, Eugenio, Rao, Arundhati, Pierce, Lisa M, Onori, Paolo, Franchitto, Antonio, Francis, Heather L, Dostal, David E, Venter, Julie K, DeMorrow, Sharon

Journal:

Laboratory Investigation

Year:

2009

Language:

english

File:

PDF, 794 KB

english, 2009

24

H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway

Francis, Heather, Franchitto, Antonio, Ueno, Yoshiyuki, Glaser, Shannon, DeMorrow, Sharon, Venter, Julie, Gaudio, Eugenio, Alvaro, Domenico, Fava, Giammarco, Marzioni, Marco, Vaculin, Bradley, Alpini,

Journal:

Laboratory Investigation

Year:

2007

Language:

english

File:

PDF, 650 KB

english, 2007

25

Knockout of α-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice

Glaser, Shannon S, Ueno, Yoshiyuki, DeMorrow, Sharon, Chiasson, Valorie L, Katki, Khurshed A, Venter, Julie, Francis, Heather L, Dickerson, Ian M, DiPette, Donald J, Supowit, Scott C

Journal:

Laboratory Investigation

Year:

2007

Language:

english

File:

PDF, 567 KB

english, 2007

26

Gastrin Inhibits Cholangiocyte Growth in Bile Duct–Ligated Rats by Interaction With Cholecystokinin-B/Gastrin Receptors viad -myo-Inositol 1,4,5-Triphosphate–, Ca2+-, and Protein Kinase C α–Dependent Mechanisms

Shannon Glaser, Antonio Benedetti, Luca Marucci, Domenico Alvaro, Leonardo Baiocchi, Noriatsu Kanno, Alessandra Caligiuri, Jo Lynne Phinizy, Usha Chowdury, Emanuela Papa, Gene LeSage, Gianfranco Alpin

Journal:

Year:

2000

Language:

english

File:

PDF, 366 KB

english, 2000

27

Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes

Gianfranco Alpini, Yoshiyuki Ueno, Shannon S. Glaser, Marco Marzioni, Jo Lynne Phinizy, Heather Francis, Gene LeSage

Journal:

Year:

2001

Language:

english

File:

PDF, 337 KB

english, 2001

28

Stimulation of α2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities

Noriatsu Kanno, Gene LeSage, Jo Lynne Phinizy, Shannon Glaser, Heather Francis, Gianfranco Alpini

Journal:

Year:

2002

Language:

english

File:

PDF, 375 KB

english, 2002

29

Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity

Gene D. LeSage, Luca Marucci, Domenico Alvaro, Shannon S. Glaser, Antonio Benedetti, Marco Marzioni, Tushar Patel, Heather Francis, Jo Lynne Phinizy, Gianfranco Alpini

Journal:

Year:

2002

Language:

english

File:

PDF, 390 KB

english, 2002

30

Functional analysis of microRNAs in human hepatocellular cancer stem cells

Fanyin Meng, Shannon S. Glaser, Heather Francis, Sharon DeMorrow, Yuyan Han, Jenna D. Passarini, Allison Stokes, John P. Cleary, Xiuping Liu, Julie Venter, Preetham Kumar, Sally Priester, Levi Hubble,

Journal:

Journal of Cellular and Molecular Medicine

Year:

2012

Language:

english

File:

PDF, 1.63 MB

english, 2012

31

Novel interaction of bile acid and neural signaling in the regulation of cholangiocyte function

Giammarco Fava, Marco Marzioni, Heather Francis, Shannon Glaser, Sharon DeMorrrow, Yoshiyuki Ueno, Antonio Benedetti, Gianfranco Alpini

Journal:

Hepatology Research

Year:

2007

Language:

english

File:

PDF, 254 KB

english, 2007

32

Divergent allosteric patterns verify the regulatory paradigm for aspartate transcarbamylase

Melinda E Wales, Lara L Madison, Shannon S Glaser, James R Wild

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 458 KB

english, 1999

33

Regulation of Biliary Proliferation by Neuroendocrine Factors: Implications for the Pathogenesis of Cholestatic Liver Diseases

Md Kamruzzaman Munshi, Sally Priester, Eugenio Gaudio, Fuquan Yang, Gianfranco Alpini, Romina Mancinelli, Candace Wise, Fanyn Meng, Antonio Franchitto, Paolo Onori, Shannon S. Glaser

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 1.20 MB

english, 2011

34

Molecular pathology of biliary tract cancers

Giammarco Fava, Marco Marzioni, Antonio Benedetti, Shannon Glaser, Sharon DeMorrow, Heather Francis, Gianfranco Alpini

Journal:

Year:

2007

Language:

english

File:

PDF, 298 KB

english, 2007

35

cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway

Heather Francis, Shannon Glaser, Yoshiyuki Ueno, Gene LeSage, Luca Marucci, Antonio Benedetti, Silvia Taffetani, Marco Marzioni, Domenico Alvaro, Julie Venter, Ramona Reichenbach, Giammarco Fava, Jo L

Journal:

Journal of Hepatology

Year:

2004

Language:

english

File:

PDF, 457 KB

english, 2004

36

The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis

Domenico Alvaro, Veronica Drudi Metalli, Gianfranco Alpini, Paolo Onori, Antonio Franchitto, Barbara Barbaro, Shannon S. Glaser, Heather Francis, Alfredo Cantafora, Ida Blotta, Adolfo Francesco Attili

Journal:

Journal of Hepatology

Year:

2005

Language:

english

File:

PDF, 374 KB

english, 2005

37

International Hepatology

Shannon S. Glaser, Gianfranco Alpini

Journal:

Journal of Hepatology

Year:

2010

Language:

english

File:

PDF, 197 KB

english, 2010

38

Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer

Gianfranco Alpini, Shannon S. Glaser, Jing-Ping Zhang, Heather Francis, Yuyan Han, Jiao Gong, Allison Stokes, Taylor Francis, Nathan Hughart, Levi Hubble, Shi-Mei Zhuang, Fanyin Meng

Journal:

Journal of Hepatology

Year:

2011

Language:

english

File:

PDF, 954 KB

english, 2011

39

Tannic Acid Inhibits Cholangiocyte Proliferation after Bile Duct Ligation via a Cyclic Adenosine 5′,3′-Monophosphate-Dependent Pathway

Silvia Taffetani, Yoshiyuki Ueno, Fanyin Meng, Julie Venter, Heather Francis, Shannon Glaser, Gianfranco Alpini, Tushar Patel

Journal:

The American Journal of Pathology

Year:

2005

Language:

english

File:

PDF, 767 KB

english, 2005

40

Ca2+-Dependent Cytoprotective Effects of Ursodeoxycholic and Tauroursodeoxycholic Acid on the Biliary Epithelium in a Rat Model of Cholestasis and Loss of Bile Ducts

Marco Marzioni, Heather Francis, Antonio Benedetti, Yoshiyuki Ueno, Giammarco Fava, Juliet Venter, Ramona Reichenbach, Maria Grazia Mancino, Ryun Summers, Gianfranco Alpini, Shannon Glaser

Journal:

The American Journal of Pathology

Year:

2006

Language:

english

File:

PDF, 1.09 MB

english, 2006

41

Estrogens and Insulin-Like Growth Factor 1 Modulate Neoplastic Cell Growth in Human Cholangiocarcinoma

Domenico Alvaro, Barbara Barbaro, Antonio Franchitto, Paolo Onori, Shannon S. Glaser, Gianfranco Alpini, Heather Francis, Luca Marucci, Paola Sterpetti, Stefano Ginanni-Corradini, Andrea Onetti Muda,

Journal:

The American Journal of Pathology

Year:

2006

Language:

english

File:

PDF, 1.91 MB

english, 2006

42

After Damage of Large Bile Ducts by Gamma-Aminobutyric Acid, Small Ducts Replenish the Biliary Tree by Amplification of Calcium-Dependent Signaling and de Novo Acquisition of Large Cholangiocyte Phenotypes

Romina Mancinelli, Antonio Franchitto, Eugenio Gaudio, Paolo Onori, Shannon Glaser, Heather Francis, Julie Venter, Sharon DeMorrow, Guido Carpino, Shelley Kopriva, Mellanie White, Giammarco Fava, Dome

Journal:

The American Journal of Pathology

Year:

2010

Language:

english

File:

PDF, 2.15 MB

english, 2010

43

α-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca2+- and PKC-dependent stimulation of cAMP

Gene D. LeSage, Domenico Alvaro, Shannon Glaser, Heather Francis, Luca Marucci, Tania Roskams, Jo Lynne Phinizy, Marco Marzioni, Antonio Benedetti, Silvia Taffetani, Barbara Barbaro, Giammarco Fava, Y

Journal:

Year:

2004

Language:

english

File:

PDF, 566 KB

english, 2004

44

Bile acid feeding induces cholangiocyte proliferation and secretion: Evidence for bile acid–regulated ductal secretion

Gianfranco Alpini*, ‡, §, Shannon S. Glaser*, Yoshiyuki Ueno¶, Rebecca Rodgers*, Jo Lynne Phinizy*, Heather Francis*, Leonardo Baiocchi*, Leigh A. Holcomb§, ∥, Alessandra Caligiuri*, Gene D. LeSage*

Journal:

Gastroenterology

Year:

1999

Language:

english

File:

PDF, 265 KB

english, 1999

45

Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct–ligated rats

Gene LeSage*, Domenico Alvaro‡, Antonio Benedetti§, Shannon Glaser∥, Luca Marucci§, Leonardo Baiocchi¶, Wendy Eisel#, Alessandra Caligiuri*, Jo Lynne Phinizy∥, Rebecca Rodgers¶, Heather Francis∥, Gian

Journal:

Gastroenterology

Year:

1999

Language:

english

File:

PDF, 256 KB

english, 1999

46

Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats

Leonardo Baiocchi, Gianfranco Alpini, Shannon Glaser, Mario Angelico, Domenico Alvaro, Heather Francis, Marco Marzioni, Jo Lynne Phinizy, Barbara Barbaro, Gene LeSage

Journal:

Journal of Hepatology

Year:

2003

Language:

english

File:

PDF, 405 KB

english, 2003

47

Estrogens induce cholangiocyte proliferation through the activation of the ERK1/2 system and the adapter proteins Sch, and Src

Domenico Alvaro, Gianfranco Alpini, Paolo Onori, Antonio Franchitto, Shannon Glaser, Gene Le Sage, Alessandro Gigliozzi, Adolfo Attili, Gianluca Svegliati Baronigaudio, Veronica Drudi Metalli, Maria G

Journal:

Journal of Hepatology

Year:

2002

Language:

english

File:

PDF, 175 KB

english, 2002

48

Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes

Domenico Alvaro, Gianfranco Alpini, Paolo Onori, Antonio Franchitto, Shannon Glaser, Gene Le Sage, Alessandro Gigliozzi, Adolfo Attili, Eugenio Gaudio

Journal:

Journal of Hepatology

Year:

2002

Language:

english

File:

PDF, 111 KB

english, 2002

49

Gamma-interferon inhibits secretin-induced choleresis and cholangiocyte proliferation in a murine model of cirrhosis

Gianfranco Alpini, Ivan Elias, Shannon S. Glaser, Rebecca E.D. Rodgers, Jo Lynne Phinizy, Willie E. Robertson, Heather Francis, John Lasater, Mark Richards, Gene D. LeSage

Journal:

Journal of Hepatology

Year:

1997

Language:

english

File:

PDF, 1.29 MB

english, 1997

50

Regulation of cholangiocyte bile secretion

Leonardo Baiocchi, Gene LeSage, Shannon Glaser, Gianfranco Alpini

Journal:

Journal of Hepatology

Year:

1999

Language:

english

File:

PDF, 1.66 MB

english, 1999